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Introducing AMP: The Accelerating Medicines Partnership
Caption: Lack of efficacy currently accounts for more than half of all drug failures in Phase II clinical studies (left). If AMP’s target validation efforts improve efficacy by 90% (right), the success...
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DNA Barcodes Interrogate Cancer Cells
Caption: A mix of cells collected from an abdominal cancer. The cancer cells (green) are positive for a cell surface cancer marker called EpCAM. The red cell is a normal mesothelial cell. The nuclei of...
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Precision Medicine: Using Genomic Data to Predict Drug Side Effects and Benefits
People with type 2 diabetes are at increased risk for heart attacks, stroke, and other forms of cardiovascular disease, and at an earlier age than other people. Several years ago, the Food and Drug...
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Fighting Parasitic Infections: Promise in Cyclic Peptides
Caption: Cyclic peptide (middle) binds to iPGM (blue). Credit: National Center for Advancing Translational Sciences, NIH When you think of the causes of infectious diseases, what first comes to mind...
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Missing Genes Point to Possible Drug Targets
Every person’s genetic blueprint, or genome, is unique because of variations that occasionally occur in our DNA sequences. Most of those are passed on to us from our parents. But not all variations are...
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How Severe COVID-19 Can Tragically Lead to Lung Failure and Death
More than 3 million people around the world, now tragically including thousands every day in India, have lost their lives to severe COVID-19. Though incredible progress has been made in a little more...
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